The National Institutes of Health (NIH) and The Centers for Disease Control and Prevention (CDC) are seeking proposals for technologies that can detect tumor-derived cell clusters. These clusters play a crucial role in metastasis and have been shown to have a higher metastatic potential than individual circulating tumor cells (CTCs). The goal is to develop technologies that can assess metastatic risk early and facilitate prompt interventions, ultimately improving cancer outcomes. The solicitation is open to Fast-Track proposals, with a total of 3-5 anticipated awards. The budget for Phase I is up to $400,000 for up to 12 months, and for Phase II, it is up to $2,000,000 for up to 2 years. Proposals exceeding the budget or project duration may not be funded. The current status of the solicitation is closed. The biology of tumor-derived cell clusters is poorly understood, and there is a need for technologies that can enrich, enumerate, and analyze these clusters to better understand their role in metastasis.