The Department of Health and Human Services, specifically the National Institutes of Health (NIH) and The Centers for Disease Control and Prevention (CDC), are seeking proposals for the development of long-acting treatments for HCV cure. The goal is to address the global issue of chronic hepatitis C virus (HCV) infection, which affects an estimated 58 million people worldwide. The solicitation aims to support research that can provide a one-dose alternative to cure HCV infection, potentially overcoming challenges related to access to diagnosis and treatment, as well as compliance with multiple drug regimens. The anticipated awards include 2-3 projects, with a budget of $300,000 for Phase I (up to 2 years) and $1 million for Phase II (up to 3 years). The development of long-acting treatments for HCV could simplify test and treat strategies, reduce healthcare infrastructure needs, and mitigate concerns about drug resistance. Ultimately, these treatments could contribute to the eradication of Hepatitis C.