The Department of Health and Human Services, specifically the National Institutes of Health, is seeking proposals for the development of medications to treat Alcohol Use Disorder (AUD) and Alcohol-Associated Organ Damage (AAOD). Currently, there are only three FDA-approved medications for AUD, and there are no approved therapies for AAOD. The goal of this funding opportunity is to advance small molecules, natural products, or biologics for AUD and AAOD through the drug development pipeline towards FDA approval and commercialization. Projects should focus on lead compounds with strong background data in basic science and early discovery phases, and should aim to achieve milestones that move the compound towards the next phase of drug development. The funding period is open until December 5, 2024, and women-owned and socially or economically disadvantaged small businesses are encouraged to apply. The research objectives include advancing small molecules, natural products, and biologics through pre-clinical development, IND-enabling toxicology, and clinical development phases. The program emphasizes the importance of adherence to compliance and quality criteria, including Good Laboratory Practices (GLP) and Good Clinical Practices (GCP). Intellectual property development and retention is strongly encouraged, and applications that focus on animal model development, basic research, or activities already funded by other sources will not be considered. For more information and to apply, visit the solicitation agency URL: link.