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The Department of Health and Human Services has issued a Notice of Funding Opportunity (NOFO) through the Agency for Healthcare Research and Quality (AHRQ) to support research on innovative digital healthcare solutions aimed at enhancing the quality of healthcare delivery at the point of care. The Phased Innovation Award (R21/R33) mechanism will provide funding over a maximum of five years, split into two phases: up to two years for initial development (R21) and up to three years for expanded research (R33), contingent upon progress made in the initial phase. The initiative encourages proposals that test digital interventions, such as artificial intelligence and patient-centered technologies, with specific focus areas including health equity, patient experiences, and decision support systems. Application deadlines commence October 16, 2024, with budgets capped at $280,000 for the R21 phase and $720,000 for the R33 phase. The emphasis is on collecting evidence to facilitate effective integration and sustainability of these technologies into clinical workflows, ultimately improving healthcare outcomes and reducing disparities among various populations. The AHRQ prioritizes research addressing underserved communities in alignment with national health objectives.