The Department of Health and Human Services has issued a Notice of Funding Opportunity (NOFO) through the National Institutes of Health (NIH) to support innovative research in medical device development aimed at preventing, monitoring, diagnosing, and treating disorders associated with various health conditions. The Blueprint MedTech Translator program encourages applications from researchers to advance clinical studies and translational activities related to medical devices while facilitating collaboration with NIH resources for design, testing, and regulatory support. Interest covers devices in diverse fields, leveraging NIH's BRAIN and HEAL Initiatives. The funding mechanism includes two phases: UG3 for initial translational activities and UH3 for subsequent clinical studies, with a total proposed project period not exceeding five years. Applicants must meet entry criteria including significant preliminary data and a compelling plan for device functionality, safety, and regulatory compliance. The application process emphasizes compliance with specific guidelines and requires detailed plans for testing, timelines, and interactions with regulatory bodies. The initiative aims to accelerate the clinical introduction of medical technologies, ultimately improving patient outcomes while ensuring adherence to best practices in research and development.