The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) for the Cardiothoracic Surgical Trials Network (CTSN) Linked Clinical Research Centers, aimed at expanding an international cardiac surgery research platform. This initiative will focus on integrating various areas of research, including interventional cardiology, peri-operative care, dissemination and implementation science, circadian medicine, and mechanistic science, to enhance the health outcomes of adults with cardiovascular disease and related neurologic complications. The platform will also serve as a training ground for future clinical trialists and implementation researchers, fostering collaboration among academia, small businesses, and other stakeholders. While applications are not currently being solicited, interested parties are encouraged to prepare for future submissions, with the estimated synopsis post date set for February 2, 2026, and the estimated project start date anticipated for January 1, 2027. For further inquiries, potential applicants can contact Dr. Kathleen Fenton at kathleen.fenton@nih.gov or by phone at 301-221-7865.

The NHLBI intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on expanding the scope of an international cardiac surgery research platform, which already includes interventional cardiology, and peri-operative care of cardiac patients. Other areas of HLBS research will be incorporated, including dissemination and implementation science, circadian medicine, and mechanistic science efforts. The predominantly public investment that created this platform will continue to utilize additional sources of funding that allow broad stakeholders, including academia, small businesses, professional societies, foundations and international research entities to collaborate and advance newer techniques, technologies, devices, and innovative pharmaceutical and bioengineered products, as well as strategies to accelerate their reach and integration, to improve the health of adults with cardiovascular disease and associated neurologic complications. Further, this enhanced platform will be used to train the next generation of clinical trialists and implementation researchers centrally. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise and insights into this area are encouraged to begin to consider applying for this NOFO. 

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