The National Institutes of Health (NIH) is set to publish a Notice of Funding Opportunity (NOFO) for the NCI Community Oncology Research Program (NCORP) Academic Community Sites, specifically for cooperative agreements where clinical trials are not allowed. This initiative aims to enhance the generalizability and dissemination of clinical trial results by engaging diverse cancer patient populations in rigorous studies focused on cancer control, prevention, treatment, and care delivery. The program anticipates awarding approximately $73 million across 50 awards, with a requirement for academic community sites to achieve a minimum of 70 unique patient accruals annually across various trial categories. Interested applicants can reach out to Brandy Heckman-Stoddard, Ph.D., M.P.H., at 240-276-7048 or via email at heckmanbm@mail.nih.gov for further details. The estimated synopsis post date is August 29, 2025, with applications closing on November 14, 2025, and awards expected to be made by August 1, 2026.

This Notice of Funding Opportunity (NOFO) is one of three NOFOs for the National Cancer Institute (NCI) Community Oncology Research Program (NCORP). NCORP is designed to enhance generalizability and dissemination of clinical trial results through accrual in a variety of community settings. The purpose of NCORP is to engage cancer patient populations, those at risk of cancer, and organizations in rigorous studies focused on cancer control, prevention, treatment and care delivery.NCORP will support the following components that will be individually awarded through the respective Request for Applications (RFAs) indicated below:NCORP Research Bases (UG1 Clinical Trials Required);NCORP Community Sites (UG1 Clinical Trials Not Allowed); andNCORP Academic Community Sites (UG1 Clinical Trials Not Allowed)NCORP Academic Community Sites are consortia of community hospitals and/or oncology practices, a public hospital, and an academic medical center that serves a patient population that can enhance the representativeness of participants accrued to cancer control, prevention, treatment and care delivery clinical trials and other human subjects research. The academic medical center should have robust infrastructure to support accrual of participants across their affiliate organizations.NCORP Academic Community Sites are expected to meet or exceed the required annual 70 new unique patient/participant accruals evenly distributed between cancer control, prevention, and screening/post-treatment surveillance trials, and treatment and imaging trials, respectively. Participation in cancer care delivery studies will be optional. For those who propose cancer care delivery participation, NCORP Academic Community Sites must meet or exceed the required minimum of 3 cancer care delivery protocols open per year. NCORP Academic Community Sites interact with the NCORP Research Bases by: 1) providing insight into clinical significance during concept development; 2) identifying care disparities in their local populations that could be studied; and 3) providing input on feasibility during protocol development.

Forecast to Publish a Notice of Funding Opportunity (NOFO) for NCI Community Oncology Research Program (NCORP) Academic Community Sites (UG1 Clinical Trials Not Allowed)

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