The Department of Health and Human Services, through the National Institutes of Health (NIH) and the National Human Genome Research Institute (NHGRI), invites applications for Small Business Innovation Research (SBIR) grants aimed at developing commercial solutions to enable population genomic screening for actionable genomic conditions in primary care. The funding opportunity (FOA) focuses on innovative technologies or services that can facilitate genomic screening efforts, manage its administration, educate primary care providers, and improve workflows. The key dates include an earliest submission date of November 1, 2024, with a total budget of up to $400,000 for Phase I and $2.15 million for Phase II applications. Eligible applicants are U.S.-based small business concerns, with emphasis on creating solutions that address barriers to screening implementation, improve access, and ensure effective follow-up care. Applications will undergo a peer review process evaluating scientific merit, innovation, and commercial potential. The initiative reflects a commitment to integrate genomics into primary care to enhance public health outcomes through proactive screening and informed patient management, adhering to strict guidelines for data management and sharing to foster collaboration in genomic research.