Broad-Spectrum Antagonists For Editors (B-SAFE)
ID: 354978Type: Posted
Overview

Buyer

DARPA - Biological Technologies Office (DOD-DARPA-BTO)

Eligible Applicants

Others

Funding Category

Science and Technology and other Research and Development

Funding Instrument

Procurement Contract

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/354978

Additional Information

https://sam.gov/opp/ce6396e6ca9c4f698ffee41fe4aa6f7f/view
Timeline
    Description

    The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the Broad-Spectrum Antagonists for Editors (B-SAFE) program, aimed at developing novel inhibitors for CRISPR-Cas gene editing technologies. The program seeks transformative approaches to discover and design inhibitors that exhibit enhanced activity and utility, with a focus on both Cas9 and Cas12 systems, while excluding incremental improvements to existing technologies. Proposals must be submitted by August 12, 2024, with an initial abstract due by July 15, 2024, and interested parties can contact the BAA Coordinator at BSAFE@darpa.mil for further information. The funding instrument is a procurement contract, and there are no cost-sharing requirements, making this an accessible opportunity for various organizations capable of meeting the government's needs.

    Point(s) of Contact
    BSAFE@darpa.mil
    Files
    Title
    Posted
    B-SAFE_QA_v2.docx
    The B-SAFE program issued by DARPA outlines a solicitation for proposals aimed at developing inhibitors for Cas9 and Cas12 DNA editors. Key details include a requirement for proposal abstracts by July 15, 2024, with feedback provided by DARPA to refine full proposals. Participation is open to international universities and non-US organizations, provided they comply with relevant legal and security regulations. There are no specified limits on team sizes or subcontracting arrangements, but proposers must finalize their teams before submitting full proposals. Proposers are advised to construct realistic budgets, and previous investments are not acceptable as cost-sharing, yet internal investments concurrent with the project may qualify. The program emphasizes inhibition of both Cas9 and Cas12, with metrics focusing on the fewest number of inhibitors achieving designated potency levels. The program will conclude with technology transitioning to US Government entities. This RFP centers on fostering technical innovation and encourages collaborative efforts to address biological editing challenges, proving crucial for safeguarding and regulatory compliance in genetic technologies.
    HR001124S0032_Attachment_B_Abstract_Template_V2.docx
    The document outlines the submission requirements for the B-SAFE Broad Agency Announcement (BAA) under the solicitation HR001124S0032 by DARPA. It mandates the use of a specific template for abstract submissions that must not exceed 4 pages, detailing the project's goals, technical approaches, and management plans. The abstract must include a cover sheet, and may not contain classified information, aligning with the formatting and submission guidelines. Proposers must detail the innovative aspects of their project, articulate the challenges and solutions, and present measurable milestones. A team’s capabilities and expertise, along with potential collaborators, should also be highlighted. After abstract submission, DARPA will provide feedback within thirty days, though this does not guarantee acceptance of a full proposal. The document stresses adherence to the deadline and submission procedures through the Broad Agency Announcement Tool, emphasizing the importance of following these guidelines for consideration in the proposal process. Overall, the focus is on fostering innovative approaches within the bounds of federal research and development opportunities.
    HR001124S0032_Attachment_C_Proposal_Summary_Slide_Template.pptx
    The HR001124S0032 B-SAFE procurement seeks innovative solutions to enhance cybersecurity. The main objective is to develop a modular, flexible, and extensible framework to counter dynamic threats. This involves creating a visual representation tool to help users understand the potential impact of various cybersecurity scenarios. The focus is on procuring a comprehensive yet customizable solution that integrates existing approaches while introducing new concepts. The tool must offer specific features, including a graphic user interface, scenario customization, and real-time updates. Vendors will need to provide detailed technical specifications and demonstrate their ability to deliver high-quality software. The work scope includes designing, developing, and testing this tool, with an emphasis on usability and scalability. The contract, valued at around $900K, is expected to be firm-fixed-price, lasting approximately three years. Key dates include a forthcoming Q&A session and a proposal submission deadline of June 2024. Evaluation will consider technical merit, with particular attention to the tool's effectiveness and innovation. This concise summary provides an overview of the B-SAFE procurement, highlighting the priority on acquiring an advanced cybersecurity visualization tool.
    HR001124S0032_Attachment_G_Risk_Register.xlsx
    The document outlines a Risk Register template for a government RFP, specifically utilizing the Department of Defense (DoD) framework for risk categorization. It specifies the elements required in the risk identification process, including a concise risk statement, estimated likelihood of occurrence rated from 1 (not likely) to 5 (near certainty), and potential consequences to the program based on cost, schedule, and performance, also rated on a scale from 1 (minimal impact) to 5 (critical impact). The risk categorization is further contextualized through a risk matrix dividing risks into high, moderate, and low categories, accompanied by proposed mitigation strategies. This framework aims to systematically assess and manage risks associated with projects outlined in federal and state/local RFPs and grants, ensuring informed decision-making and effective resource allocation throughout the program lifecycle. The comprehensive structure of the document supports risk management practices crucial for maintaining project integrity and alignment with federal guidelines.
    HR001124S0032-Amendment-01.pdf
    Amendment 1 to HR001124S032, the B-SAFE Broad Agency Announcement, aims to clarify proposal submission requirements, particularly for Tables 1 and 4, and introduces a Risk Register attachment. It outlines deliverables across three phases of the program, including monthly technical and financial reports, various Capability Demonstration (CD) reports, a Transition Plan, and a Technology Transfer Package. Additionally, it specifies performance metrics for technical areas related to potency and novel inhibitor development. The announcement allows for multiple types of award instruments, such as Procurement Contracts and Cooperative Agreements, with specific cost-sharing requirements. Proposers must submit abstracts for eligibility and full proposals are due by August 12, 2024, with various required attachments detailing proposal structure and content. This document serves as a crucial guideline for organizations seeking to engage in government-funded research initiatives, aligning with broader objectives for developing broad-spectrum antagonists in response to specific challenges identified by the U.S. Government.
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