Novel Approaches to Advance Precision Aging and Cognitive Health
ID: 360910Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes
Timeline
    Description

    The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) titled "Novel Approaches to Advance Precision Aging and Cognitive Health," aimed at soliciting applications that leverage innovative study designs and methods, including machine learning and artificial intelligence, to enhance cognitive health in older adults. This initiative seeks to develop personalized prevention plans and interventions by discovering health and function profiles at the individual level, encompassing research from cellular to societal levels. The grant will utilize the R01 activity code, with applications not currently being solicited; however, potential applicants are encouraged to begin forming collaborations and project ideas in anticipation of the funding opportunity. For further inquiries, interested parties may contact Dr. Molly Wagster at wagsterm@nia.nih.gov or by phone at 301-496-9350. The estimated synopsis post date is August 6, 2026, with a close date of October 6, 2026, and an anticipated award date of July 6, 2027.

    Point(s) of Contact
    Files
    No associated files provided.
    Similar Opportunities
    Notice of Intent to Publish a Notice of Funding Opportunity for Early- and Late-Stage Clinical Trials for the Spectrum of Alzheimer's Disease/Alzheimer's Disease-Related Dementias and Age-Related Cognitive Decline (R01 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) intends to publish a Notice of Funding Opportunity (NOFO) for early- and late-stage clinical trials focused on Alzheimer's Disease, Alzheimer's Disease-Related Dementias, and age-related cognitive decline. This initiative aims to invite applications that propose innovative pharmacological and non-pharmacological interventions to address cognitive and behavioral changes associated with these conditions, as well as to enhance trial design and methodologies. The NOFO is expected to be published in December 2024, with application due dates in March, June, and October of 2025, and an estimated award date set for December 1, 2025. Interested applicants are encouraged to prepare collaborative projects in advance, as there are no cost-sharing requirements associated with this grant opportunity.
    Understanding Cerebellar Contributions to Cognitive and Affective Functions in Aging and Alzheimer's Disease/Alzheimer's Disease-Related Dementias
    National Institutes of Health
    The National Institutes of Health (NIH) is announcing a forthcoming Notice of Funding Opportunity (NOFO) aimed at advancing research on the cerebellum's role in cognitive and affective functions related to aging and Alzheimer's disease (AD) as well as Alzheimer's disease-related dementias (ADRD). This initiative seeks to enhance understanding of the cerebellum's physiology and neuroanatomy, encouraging a variety of research approaches, including basic studies, secondary data analyses, and intervention-focused research. The NOFO is particularly significant as it aims to identify potential targets for interventions that could promote cognitive reserve and delay the onset of AD/ADRD. Interested researchers are encouraged to prepare collaborative proposals, with applications expected to be solicited in the future; for inquiries, contact Matt Sutterer, Ph.D., at matt.sutterer@nih.gov. The estimated synopsis post date is August 6, 2026, with a projected award date of July 6, 2027.
    Interdisciplinary Research to Understand the Complex Biology of Resilience to Alzheimer’s and Related Dementias Disease Risk
    National Institutes of Health
    The National Institutes of Health (NIH) is announcing a forthcoming funding opportunity titled "Interdisciplinary Research to Understand the Complex Biology of Resilience to Alzheimer's and Related Dementias Disease Risk." This initiative aims to foster research that integrates epidemiologic, genomic, and mechanistic studies to uncover the molecular and cellular determinants of resilience against Alzheimer's disease (AD) and related dementias (ADRD) through data-driven, systems-based approaches, including artificial intelligence and machine learning. The program is particularly significant as it seeks to generate high-dimensional molecular data from brain and peripheral tissues, facilitating the discovery of molecular predictors of resilience across diverse populations. While applications are not currently being solicited, interested researchers are encouraged to prepare collaborative projects in anticipation of the opportunity, which is expected to utilize the U01 activity code. For further inquiries, potential applicants can contact Dr. Suzana Petanceska at petanceskas@nia.nih.gov or by phone at 301-496-9350. The estimated synopsis post date is February 26, 2026, with a projected award date of April 5, 2027.
    Early- and Late-Stage Clinical Trials for the Spectrum of Alzheimer's Disease/Alzheimer's Disease-Related Dementias and Age-Related Cognitive Decline
    National Institutes of Health
    The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) aimed at supporting early- and late-stage clinical trials focused on Alzheimer's Disease (AD), Alzheimer's Disease-Related Dementias (ADRD), and age-related cognitive decline. This initiative seeks applications that propose innovative pharmacological and non-pharmacological interventions to address cognitive, behavioral, and neuropsychiatric changes associated with these conditions, as well as studies to enhance trial design and methodologies. The funding opportunity, categorized under health-related discretionary grants, is intended for small businesses with expertise in aging research, with an estimated synopsis posting date of August 1, 2025, and a closing date for applications expected by October 5, 2025. For further inquiries, interested applicants can contact Laurie Ryan, Ph.D., at 301-496-9350 or via email at ryanl@mail.nih.gov.
    Mechanisms Underlying Olfactory Dysfunction in Aging and Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias
    National Institutes of Health
    The National Institutes of Health (NIH) is set to publish a Notice of Funding Opportunity (NOFO) aimed at investigating the mechanisms underlying olfactory dysfunction in aging, Alzheimer’s disease (AD), and Alzheimer’s disease-related dementias (ADRD). This initiative seeks to explore the relationship between olfactory decline and various health outcomes in older adults, potentially identifying novel therapeutic targets for disease modification. The research may involve studies on older adults and animal models, utilizing diverse methodologies such as cellular, molecular, and imaging techniques. While applications are not currently being solicited, interested researchers are encouraged to prepare collaborative projects in anticipation of the funding opportunity, which is expected to utilize the R01 activity code. For further inquiries, contact Coryse St. Hillaire-Clarke, Ph.D., at 301-496-9350 or via email at sthillaireclacn@mail.nih.gov. The estimated synopsis post date is August 6, 2026, with a closing date for applications anticipated on October 6, 2026, and awards expected to be made by July 6, 2027.
    Notice of Intent to Publish a Funding Opportunity Announcement for Facilitating Preclinical and Early Phase Human Studies for New Therapeutics (UG3/UH3 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) plans to publish a Notice of Funding Opportunity (NOFO) for facilitating preclinical and early phase human studies for new therapeutics, specifically targeting aging-related conditions. This initiative aims to advance T1 translational aging research, focusing on therapeutics that progress from preclinical stages to first-in-human trials, addressing conditions such as sarcopenia and heart failure with preserved ejection fraction (HFpEF). The funding opportunity, categorized under health-related activities, will utilize the UG3/UH3 Cooperative Agreement mechanism, with an estimated total program funding of $2.5 million. Interested applicants should prepare to submit their applications by fall 2024, with the NOFO expected to be published in summer 2024 and awards anticipated by July 2025.
    Renewal of the Clinician-Scientists Transdisciplinary Aging Research (Clin-STAR) Coordinating Center
    National Institutes of Health
    The National Institutes of Health (NIH) is preparing to release a Notice of Funding Opportunity (NOFO) for the renewal of the Clinician-Scientists Transdisciplinary Aging Research Coordinating Center (Clin-STAR CC), aimed at enhancing aging research across various clinical disciplines. This initiative seeks to support clinician-investigators by providing a national resource that fosters collaboration, mentorship, and interdisciplinary research projects focused on aging, ultimately improving patient-centered care for older adults. The funding will also prioritize geographic representation and diversity among early career clinician-scientists in aging research. While applications are not currently being solicited, interested parties can prepare for the opportunity, with the estimated synopsis posting date on August 17, 2025, and a projected award date of July 17, 2026. For further inquiries, contact Alexis Bakos, Ph.D., MPH, RN at alexis.bakos@nih.gov or call 301-480-8538.
    Notice of Intent to Publish a Notice of Funding Opportunity for Centers on the Demography and Economics of Aging, Including Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD) (D&E Centers) (P30 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) plans to publish a Notice of Funding Opportunity (NOFO) for the development or renewal of Research and Development Centers (P30) focused on the demography and economics of aging, particularly concerning Alzheimer’s disease and related dementias (AD/ADRD). The program aims to seed innovative research, integrate health disparity approaches, and engage a diverse range of scholars across disciplines, providing a structured support system for pilot projects and data sharing. With an estimated total program funding of $9 million and an award ceiling of $600,000, the NOFO is expected to be published in July 2024, with applications due by October 2024 and awards anticipated by June 2025. Interested applicants are encouraged to prepare collaborative proposals in advance of the application period.
    Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research (R01 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) is set to publish a Notice of Funding Opportunity (NOFO) for the Advancing Bioinformatics, Translational Bioinformatics, and Computational Biology Research initiative, which aims to support innovative research in these fields. This initiative seeks to develop advanced methods and tools that leverage transformative technologies, such as artificial intelligence and machine learning, to enhance the interpretation of complex biological datasets, ultimately improving health outcomes. With an estimated total program funding of $2.5 million and the expectation of awarding approximately 10 grants, interested small businesses are encouraged to prepare their applications, with the anticipated synopsis posting date on October 6, 2025, and a closing date for applications on February 4, 2026. For further inquiries, potential applicants can contact Dr. Catherine Farrell at catherine.farrell@nih.gov or by phone at 301-402-7081.
    Discovery of in vivo Chemical Probes for the Nervous System
    National Institutes of Health
    The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) aimed at supporting the discovery of in vivo chemical probes for the nervous system, specifically targeting novel brain mechanisms. This initiative, led by the National Institute on Aging (NIA) in collaboration with the National Eye Institute (NEI), the National Institute on Drug Abuse (NIDA), and the National Institute of Mental Health (NIMH), seeks applicants who possess validated starting compounds for chemical optimization and bioassays to explore new analog compounds. The focus will be on developing small molecules that can enhance understanding of biological processes relevant to brain diseases, with an emphasis on innovative biological targets. Interested applicants can reach out to Dr. Paul G. Grothaus at grothausp@mail.nih.gov or call 240-688-6634 for further information, with the estimated synopsis posting date set for February 26, 2026, and a projected award date of April 5, 2027.