The Centers for Disease Control and Prevention (CDC) announces its intent to fund the Preventive Health and Health Services Block Grant for Fiscal Year 2025, with an estimated budget of $162 million. This program under Public Law 115-245 allows recipients, including all U.S. states, certain tribes, and U.S. territories, to address unique public health challenges using innovative and locally defined methods. The funding prioritizes community-driven solutions to prevent diseases, improve health infrastructure, and monitor health disparities within targeted populations. Key goals include addressing emerging health issues, decreasing premature deaths related to preventable risk factors, and supporting local health programs. Applications for funding will be submitted through the Public Health Infrastructure Virtual Engagement (PHIVE) platform, with proposals due by July 31, 2025, and awards expected by September 15, 2025. Specific unallowable costs, such as the purchase of naloxone, clinical care, and lobbying expenses, are detailed to ensure funds are allocated appropriately. The initiative reflects CDC’s commitment to enhancing public health outcomes while fostering state and local agency priorities.