The National Institutes of Health (NIH) intends to publish a Notice of Funding Opportunity (NOFO) for the Alzheimer’s Clinical Trials Consortium (ACTC) aimed at developing and implementing multi-site Phase Ib to III clinical trials for interventions targeting Alzheimer’s disease (AD) and related dementias (ADRD). This initiative seeks applications for promising pharmacological and non-pharmacological strategies that may prevent, delay, or treat the symptoms of AD, utilizing the ACTC's trial coordination and management infrastructure. The NOFO is significant as it addresses a critical health challenge, and it is expected to be published in December 2024, with application due dates in March, June, and October of 2025. Interested applicants should prepare for the R01 activity code funding, with an estimated award date set for December 1, 2025.