The U.S. Department of Energy (DOE) Office of Science has announced a Notice of Funding Opportunity (NOFO) for Research, Development, and Training in Isotope Production, designated as DE-FOA-0003530. This initiative aims to advance research in isotope enrichment, production, and purification techniques, with a particular focus on artificial intelligence, novel chemistries, and advanced manufacturing processes. Isotopes play a critical role in various fields, including medicine, national security, and advanced manufacturing, and this funding opportunity supports the DOE's mission to ensure the availability of essential isotopes in the U.S. Up to $11 million is available for 8 to 12 awards, ranging from $100,000 to $750,000 each, for projects lasting two years, with pre-applications due by February 17, 2025, and final applications by April 17, 2025. For further inquiries, interested parties can contact Ethan Balkin, Ph.D., at ethan.balkin@science.doe.gov or by phone at 301-903-1861.