The Department of Health and Human Services, through the National Institutes of Health (NIH), announces a funding opportunity (FON: PAR-25-094) aimed at researching the impacts of climate change on the cancer control continuum. This funding opportunity supports innovative studies focused on understanding and mitigating the effects of climate change on cancer risk, prevention, and survivorship. Applicants are encouraged to explore how environmental changes influence cancer risks and healthcare delivery disruptions while emphasizing health inequities among vulnerable populations. The application process begins on January 5, 2025, with various submission due dates extending until February 2026. Eligible organizations include higher education institutions, non-profits, for-profits, and local governments. The maximum project period is five years with no set budget limit. Reviews will assess scientific merit based on significance, innovation, rigor, and the expertise of the investigative teams. Successful proposals must include climate change expertise and may involve diverse research approaches. This initiative is crucial in responding to the growing health challenges posed by climate change and aligning with NIH’s goal to enhance public health through advanced research.