Population Genomic Screening in Primary Care Cooperative Agreement (U01 - Clinical Trial Required)
ID: 356076Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/356076

Additional Information

http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-24-021.html
Timeline
    Description

    The National Institutes of Health (NIH) has announced a Notice of Funding Opportunity (NOFO) titled "Population Genomic Screening in Primary Care Cooperative Agreement" (RFA-HG-24-021), aimed at implementing and evaluating genomic screening in primary care settings. The initiative seeks to establish a network of 4-5 Clinical Groups (CGs) to screen 4-8 actionable genomic conditions in diverse populations, with a focus on health disparity populations, while employing comprehensive community engagement strategies. This $3.85 million funding opportunity over five years is designed to enhance preventive care and public health outcomes by integrating genomic research into routine healthcare practices. Interested applicants can find more information and submit inquiries via grantsinfo@nih.gov, with applications due by December 2, 2024.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    RFA-HG-24-021-Full-Announcement.html
    RFA-HG-24-021.html
    The Department of Health and Human Services, through the National Institutes of Health (NIH), has issued a Notice of Funding Opportunity (NOFO) under the title "Population Genomic Screening in Primary Care Cooperative Agreement" (RFA-HG-24-021) aimed at generating evidence through pilot programs for genomic screening in primary care settings. The funding, totaling $3.85 million over five years, seeks to establish a network of 4-5 Clinical Groups (CGs) that will engage primary care providers to implement screening for 4-7 genomic conditions recognized as actionable by the CDC, addressing disparities in healthcare access. Key objectives for the CGs include screening 5,000 diverse patients with an emphasis on health disparity populations, employing comprehensive community engagement strategies, and ensuring data sharing and follow-up. This initiative is designed to build infrastructure for equitable genomic screening, improve understanding of implementation processes, and create frameworks for best practices. The project emphasizes the incorporation of patient feedback and involvement throughout, aligning with NIH policies for genomic data sharing and clinical trial registration. Overall, this NOFO represents a significant federal investment in the field of population genomics, focusing on integrating genomic research into routine primary healthcare practices to enhance preventive care and public health outcomes.
    Similar Opportunities
    Investigator-Initiated Research in Genomics and Health Equity (R21 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Investigator-Initiated Research in Genomics and Health Equity (R21 Clinical Trial Optional)" aimed at supporting small-scale research projects that enhance health equity through genomic research. The initiative seeks to develop innovative approaches and metrics to ensure the equitable application of genomics in improving health outcomes for U.S. populations, particularly focusing on historically underrepresented groups in biomedical research. Eligible applicants include a wide range of organizations, such as higher education institutions, nonprofit organizations, and state governments, with funding available up to $200,000 annually for a maximum of two years. Interested parties should submit their applications by July 8, 2025, and can direct inquiries to NIH Grants Information at grantsinfo@nih.gov or visit the opportunity's webpage for more details at https://grants.nih.gov/grants/guide/rfa-files/RFA-HG-23-018.html.
    Genomic Community Resources (U24 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity (PAR-23-124) aimed at supporting the development of genomic community resources through cooperative agreements. This initiative seeks to enhance genomic research by funding projects that demonstrate broad applicability and significant value, focusing on the creation of genomic informatics tools, biological material collections, and community engagement efforts. The funded projects will play a crucial role in advancing both basic and clinical genomics research, with awards potentially lasting up to five years. Interested applicants, including a diverse range of organizations such as higher education institutions and nonprofits, must submit their applications by January 25, 2026, and can find further details and submission guidelines at NIH Grants. For inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov.
    ClinGen Genomic Curation Expert Panels (U24 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering funding through the opportunity titled "ClinGen Genomic Curation Expert Panels (U24 Clinical Trial Not Allowed)" to establish Expert Panels focused on the clinical relevance of genetic variants. The primary objective of this initiative is to develop a comprehensive knowledge base that enhances the interpretation of genes and genomic variants associated with high-priority diseases, utilizing established tools and resources from the Clinical Genomics Resource (ClinGen) and ClinVar. This funding is crucial for advancing genomic research and improving clinical outcomes through precision medicine, with a maximum award ceiling of $220,000 per year for a grant period of up to three years. Interested applicants must submit their proposals by May 25, 2025, and can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.
    Single Source: The NIGMS Human Genetic Cell Repository (U42 - Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a non-competitive funding opportunity for a cooperative agreement to support the Human Genetic Cell Repository (HGCR), with a focus on maintaining and distributing a diverse collection of human cell lines and DNA samples for biomedical research. The initiative aims to enhance the repository's capacity by acquiring new cell lines from diverse populations, ensuring ethical practices in sample collection, and promoting inclusivity in research efforts. This funding opportunity provides up to $1.75 million annually for a five-year project period, with applications due by June 10, 2026. Interested applicants can find more information and contact NIH Grants Information at grantsinfo@nih.gov or visit the funding announcement at https://grants.nih.gov/grants/guide/pa-files/PAR-24-055.html.
    Centers of Excellence in Genomic Science (RM1 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity for the Centers of Excellence in Genomic Science (CEGS) program, aimed at supporting innovative, interdisciplinary research in genomic science. This program seeks to establish academic centers that will develop transformative genomic approaches to address significant biomedical challenges, with a focus on integrating advanced technological and computational methods. Each award can provide up to $1.5 million per year for a maximum of five years, with potential renewal for an additional five years, and applications are due by June 23, 2025. Eligible applicants include a range of institutions such as higher education entities, nonprofits, and various government organizations, while foreign entities are not eligible. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov.
    Notice of Intent to Publish a Funding Opportunity Announcement for Transforming NHGRI�s Diversity Action Plan (R25 Clinical Trials Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) plans to publish a Funding Opportunity Announcement (FOA) aimed at transforming the National Human Genome Research Institute's (NHGRI) Diversity Action Plan (R25 Clinical Trials Not Allowed) to enhance workforce diversity in genomics. This initiative seeks to support the training, employment, and retention of individuals from underrepresented backgrounds in the biomedical workforce, aligning with NHGRI's strategic objectives to foster diverse scientific teams that drive innovation and creativity. The FOA is expected to be published in Summer 2023, with applications due in Early 2024, and the estimated award date is set for September 9, 2024. For further inquiries, interested parties can contact Dr. Lucia A. Hindorff at hindorffl@mail.nih.gov.
    Notice of Intent to Publish a Funding Opportunity Announcement for Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) plans to publish a funding opportunity announcement for the "Supporting Talented Early Career Researchers in Genomics" program, utilizing the R01 activity code. This initiative aims to provide financial support to early career researchers in the field of genomics, facilitating the development of innovative projects that contribute to the understanding of human genetics. The estimated total program funding is $2 million, with an award ceiling of $400,000 per project, and the application period is expected to open on December 18, 2024, with a closing date of February 28, 2025. Interested applicants should prepare their proposals in advance, as the estimated award date is set for December 31, 2025.
    Screening and Functional Validation of Human Birth Defects Genomic Variants (R01 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled "Screening and Functional Validation of Human Birth Defects Genomic Variants (R01 Clinical Trial Not Allowed)" aimed at advancing research on congenital defects linked to genetic variants. This initiative encourages the use of cutting-edge genotyping and sequencing technologies to validate genetic variants identified through public databases, bridging the gap between variant identification and understanding their functional impacts on developmental outcomes. The funding is available to a diverse range of eligible organizations, including higher education institutions and nonprofits, with an annual budget cap of $499,999 and a project period of up to five years. Interested applicants should contact the NIH OER Webmaster at grantsinfo@nih.gov for assistance and must submit their proposals by May 7, 2025, to be considered for this significant funding opportunity.
    Innovative Screening Approaches and Therapies for Screenable Disorders in Newborns (R21 - Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Innovative Screening Approaches and Therapies for Screenable Disorders in Newborns (R21 - Clinical Trial Optional)" aimed at promoting research and development of novel screening methods and therapeutic interventions for conditions identified through newborn screening. This initiative encourages innovative projects that generate preliminary data on both existing and potentially fatal genetic disorders, emphasizing the importance of early detection and intervention. The program is open to a wide range of eligible applicants, including higher education institutions, nonprofits, and governmental bodies, with a total funding ceiling of $275,000 over two years. Interested applicants should note that the submission deadlines begin on January 16, 2025, and can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.
    Limited Competition: Competing Revisions to Support Clinical Trials in Somatic Cell Genome Editing (U19 Clinical Trial Required)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a Notice of Funding Opportunity (NOFO) for competitive revisions to support clinical trials in somatic cell genome editing, specifically under the funding opportunity RFA-RM-24-008. This initiative aims to expand the existing Somatic Cell Genome Editing program by soliciting applications from awardees with active U19 awards funded under RFA-RM-22-015, which previously did not allow clinical trials. The funding will facilitate first-in-human genome editing clinical trials, including essential preparatory activities such as patient recruitment, regulatory approvals, and the development of clinical trial designs. Interested applicants must submit their proposals by February 13, 2026, and can find additional information and submission guidelines at the NIH grants website or contact NIH Grants Information at grantsinfo@nih.gov.