The Centers for Disease Control and Prevention (CDC) is offering grants under the Comprehensive Addiction and Recovery Act (CARA) to support community-based coalitions addressing the misuse of opioids, methamphetamines, and prescription drugs among youth aged 12-18. Eligible applicants include nonprofit organizations, state and local governments, and other entities that have documented higher-than-average rates of substance misuse in their communities, specifically those that are current or former recipients of the Drug-Free Communities (DFC) Support Program. This initiative aims to enhance coalition activities to combat local drug crises and is part of a broader commitment to protect American youth from the dangers of drug use. The total estimated funding for this program is $18.75 million, with individual awards ranging from $0 to $75,000, and applications are due by April 28, 2026. For further inquiries, interested parties can contact Christi Jones at CARA_NOFO@cdc.gov.