The Centers for Disease Control and Prevention (CDC) is offering grants under the Comprehensive Addiction and Recovery Act (CARA) to support community-based coalitions addressing the crises of opioid, methamphetamine, and prescription drug misuse among youth aged 12-18. Eligible applicants include nonprofit organizations, state and local governments, and other entities that have documented higher-than-average rates of substance misuse, specifically those that are current or former recipients of the Drug-Free Communities (DFC) Support Program. This initiative aims to enhance coalition activities to prevent and reduce substance use among American youth, with a total estimated funding of $16,875,000 available for approximately 45 awards, each ranging from $0 to $75,000. Interested parties should submit their applications electronically by March 16, 2026, and can direct inquiries to Christi Jones at CARA_NOFO@cdc.gov.