The Centers for Disease Control and Prevention (CDC) is inviting applications for the Comprehensive Addiction and Recovery Act (CARA) Community-based Coalition Enhancement Grants to Address Local Drug Crises, aimed at preventing and reducing opioid and methamphetamine use among youth aged 12-18. Eligible applicants include community-based coalitions that are nonprofit organizations or associated with recognized nonprofits, and they must demonstrate higher-than-average rates of substance misuse in their communities. This grant program, with an estimated total funding of $16,875,000 and an award ceiling of $75,000, is designed to enhance the efforts of current or former Drug-Free Communities Support Program recipients. Interested parties must submit their applications electronically by January 21, 2026, to the contact email CARA_NOFO@cdc.gov for further inquiries.