The Department of Health and Human Services announces the NINDS Alzheimer’s Disease-Related Dementias (ADRD) Advanced Postdoctoral Career Transition Award (K99/R00) aimed at supporting rising independent investigators in dementia research. This funding opportunity facilitates the transition from mentored postdoctoral positions to independent faculty roles, offering two phases of funding: a mentored phase (K99) for up to two years and an independent phase (R00) for up to three years. Candidates, holding no more than four years of postdoctoral experience, must propose research that does not lead independent clinical trials, while still engaging with clinical trial experiences under mentorship. The initiative emphasizes biomedical research in ADRD, covering various research areas like basic biological mechanisms, disease comparisons, and clinical diagnostics. The awards depend on NIH appropriations, with a specified salary support structure and research costs, conditional on progress during the K99 phase and securing an independent position for R00 eligibility. The application process mandates compliance with extensive instructions, eligibility criteria, and a focus on career development for underrepresented groups in research. The initiative reflects NIH's goal to enhance the scientific workforce addressing dementia-related challenges.