The National Institutes of Health (NIH) is announcing a forthcoming funding opportunity titled "Interdisciplinary Research to Understand the Complex Biology of Resilience to Alzheimer's and Related Dementias Disease Risk." This initiative aims to foster research that integrates epidemiologic, genomic, and mechanistic studies to uncover the molecular and cellular determinants of resilience against Alzheimer's disease (AD) and related dementias (ADRD) through data-driven, systems-based approaches, including artificial intelligence and machine learning. The program is particularly significant as it seeks to generate high-dimensional molecular data from brain and peripheral tissues, facilitating the discovery of molecular predictors of resilience across diverse populations. While applications are not currently being solicited, interested researchers are encouraged to prepare collaborative projects in anticipation of the opportunity, which is expected to utilize the U01 activity code. For further inquiries, potential applicants can contact Dr. Suzana Petanceska at petanceskas@nia.nih.gov or by phone at 301-496-9350. The estimated synopsis post date is February 26, 2026, with a projected award date of April 5, 2027.