The Centers for Disease Control and Prevention (CDC) is offering a Public Health Emergency Preparedness (PHEP) Cooperative Agreement aimed at enhancing the capabilities of state, tribal, local, and territorial public health systems to effectively prepare for, respond to, and recover from public health threats and emergencies. This funding opportunity seeks to strengthen readiness and response strategies, particularly for organizations that are currently funded under CDC-RFA-TP19-1901, and includes specific eligibility for state and local governments, including Chicago, Los Angeles County, New York City, and Washington, D.C. The total estimated program funding is approximately $3.27 billion, with individual awards ranging from $370,000 to $50 million, and a total of 62 awards expected. Interested applicants must submit their applications electronically by April 24, 2024, and can direct inquiries to James Diggs at vqh3@cdc.gov.