The Department of Health and Human Services is reissuing a Notice of Funding Opportunity (NOFO) for the Cancer Intervention and Surveillance Modeling Network (CISNET) (RFA-CA-25-032). This NOFO, with an application due date of February 11, 2026, seeks applications for collaborative research projects utilizing simulation and other modeling techniques for specific cancer types (bladder, breast, cervix, colon/rectum, esophagus, gastric, multiple myeloma, lung, prostate, and uterine). The primary goal is to generate evidence-based tools to inform decisions on efficient utilization of technologies and strategies for cancer control, ultimately reducing cancer risk, incidence, morbidity, and mortality. The program focuses on comparative modeling, with each application requiring 2-6 independent modeling teams and one coordinating center. Key priority areas include understanding cancer control efforts, evaluating emerging technologies, informing precision treatment, and improving outcomes in at-risk populations. The NCI intends to commit $9.438M in FY 2026 to fund up to eight awards, with a maximum project period of five years. Applications are limited to a single cancer type, must employ a comparative modeling approach, and cannot involve de novo model development or primary data collection. All applicants must adhere to strict submission guidelines, including specific budget allocations for modeling groups and a coordinating center, and must include a “Model Accessibility Plan”.