The Centers for Disease Control and Prevention (CDC) is offering a cooperative agreement opportunity aimed at sustaining HIV and TB epidemic control in Lesotho through health system strengthening and technical assistance under the President's Emergency Plan for AIDS Relief (PEPFAR). The initiative seeks to achieve the UNAIDS 95-95-95 targets by implementing evidence-based interventions and innovative strategies in the districts of Leribe, Berea, Quthing, and Qacha’s Nek, while collaborating closely with the Ministry of Health to enhance health service delivery. This funding opportunity, with an estimated total of $15 million for the first fiscal year, is open to unrestricted applicants, and interested parties must submit their applications electronically by February 17, 2026, to be considered for the anticipated awards, which are expected to be announced by September 30, 2026. For further inquiries, applicants can contact the grantor at pepfarfoas@cdc.gov.