The National Institutes of Health (NIH) is offering the Directors Pioneer Award Program (DP1 Clinical Trial Optional), a federal grant aimed at supporting innovative scientists proposing bold research projects with significant potential impacts on human health. This program encourages applications from a diverse pool of researchers, including those from underrepresented groups and various eligible institutions, to foster groundbreaking ideas across all areas relevant to the NIH mission. Each selected investigator will receive an award budget of up to $700,000 per year for five years, totaling approximately $8 million for FY 2025, with applications due by September 9, 2024. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov or visit the program's announcement page at https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-24-002.html.