Assay development and screening for discovery of chemical probes, drugs or immunomodulators (R01 Clinical Trial Not Allowed)
ID: 349827Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/349827

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-23-264.html
Timeline
    Description

    The National Institutes of Health (NIH), through the National Cancer Institute (NCI), has announced a funding opportunity titled "Assay development and screening for discovery of chemical probes, drugs or immunomodulators (R01 Clinical Trial Not Allowed)." This initiative invites applications for the identification and development of small molecules that can elucidate disease biology or serve as therapeutic agents, with a focus on advancing research related to cancer treatment. The program encompasses various stages of discovery research, including assay development, high-throughput screening, hit validation, and optimization of lead compounds, encouraging innovative methodologies to enhance understanding of cancer biology. Interested applicants, including a wide range of institutions and organizations, must submit their proposals by September 7, 2026, and can find additional information and application guidelines at the NIH grants website or contact NIH Grants Information at grantsinfo@nih.gov.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    PAR-23-264-Full-Announcement.html
    PAR-23-264.html
    The Department of Health and Human Services, through the National Cancer Institute (NCI), has issued a Notice of Funding Opportunity (NOFO) aimed at advancing research in the discovery and development of novel small molecules for cancer treatment. This initiative, reissuing the funding opportunity PAR-20-271 under NOFO number PAR-23-264, seeks proposals for the development of assays and screening for potential chemical probes or drugs. The eligible applicants include various institutions, nonprofits, and foreign entities, with an emphasis on promoting research related to underrepresented cancer targets and pathways. Key research stages include developing primary screening assays, implementing high-throughput screens, and validating initial hits through comprehensive follow-up assays. The program encourages innovative approaches and robust methodologies to ensure the relevance of compounds in understanding cancer biology and therapeutic strategies. Applications are expected to address specific aspects of assay design, screening implementation, and hit validation while collaborating with experts in medicinal chemistry and screening technologies. The funding will support grants for up to three years, contingent upon the successful application and available NIH appropriations, reflecting a commitment to bolster the fight against cancer through scientific discovery.
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