The National Institutes of Health (NIH) is offering the Tobacco Regulatory Science Small Grant Program for New Investigators (R03 Clinical Trial Optional) to support early-stage researchers in tobacco regulatory science. This funding opportunity aims to facilitate small-scale projects that generate data to inform the U.S. Food and Drug Administration's (FDA) regulations on tobacco products, in alignment with the Family Smoking Prevention and Tobacco Control Act (FSPTCA). Eligible applicants include various organizations such as higher education institutions, non-profits, and government entities, with awards of up to $75,000 available for projects lasting up to two years, and a total funding pool of $500,000 anticipated for fiscal year 2026. Interested applicants should submit their proposals through Grants.gov and eRA Commons by the closing date of July 14, 2026, and can direct inquiries to grantsinfo@nih.gov for further information.

RFA-OD-25-008-Full-Announcement.html

RFA-OD-25-008.html

The Department of Health and Human Services, along with the National Institutes of Health (NIH) and the U.S. Food and Drug Administration (FDA), announces the Tobacco Regulatory Science Small Grant Program (R03) aimed at supporting early-stage investigators in tobacco regulatory research. This funding opportunity, identified as RFA-OD-25-008, encourages small-scale projects that can contribute valuable data for informing FDA's regulations on tobacco products, pursuant to the Family Smoking Prevention and Tobacco Control Act (FSPTCA). 

Eligible applicants include higher education institutions, non-profits, and governments, with awards of up to $75,000 for a project duration of two years, totaling an anticipated funding pool of $500,000 for the fiscal year 2026. Research must align with specific high-priority topics, focusing on tobacco addiction, health effects, product composition, and emerging tobacco products. The application process requires registrants to utilize Grants.gov and eRA Commons, with strict guidelines governing compliance, submission, and eligibility criteria. The program aims to foster research that informs public health policies and contributes to evidence-based regulatory actions to protect public health concerning tobacco use.

https://grants.nih.gov/grants/guide/rfa-files/RFA-OD-25-008.html

This Notice of Funding Opportunity (NOFO) aims to support new biomedical, behavioral, and social science investigators who are in the early stages of establishing independent careers in tobacco regulatory research. The R03 grant mechanism supports different types of projects, including pilot and feasibility studies, secondary analysis of existing data, small, self-contained research projects, development of research methodology, and development of new research technology. Applicants are encouraged to conduct projects that ultimately have the potential to inform regulations on tobacco product manufacturing, distribution, and marketing. Research projects must address one or more High-Priority Research Topic(s) related to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP) as mandated by the Family Smoking Prevention and Tobacco Control Act (FSPTCA), Public Law 111-31. The awards under this NOFO will be administered by NIH using funds made available through FDA CTP and the FSPTCA. Research results from this NOFO are expected to generate findings and data directly relevant to informing the FDA&apos;s regulation of the manufacture, distribution, and marketing of tobacco products to protect public health.

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

NIH Grants Information&lt;br/&gt;grantsinfo@nih.gov

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