The Department of Health and Human Services is inviting applications for a Sequencing Center as part of a pilot program focused on population genomic screening for actionable genetic conditions in primary care. This initiative, under the funding opportunity number RFA-HG-24-023, aims to implement a network in collaboration with clinical groups and a coordinating center. The program seeks to evaluate genomic screening effectiveness for conditions like hereditary breast and ovarian cancer, Lynch syndrome, and familial hypercholesterolemia, with an emphasis on community engagement and equitable health outcomes. Key objectives include enrolling 5,000 patients per clinical group while ensuring at least 55% belong to health disparity populations, performing whole exome sequencing, and facilitating appropriate follow-up and care connections. The project's success hinges on streamlined workflows, integration of results into electronic health resources, and the sharing of lessons learned to enhance future genomic screening efforts. The anticipated funding will support a total budget of approximately $5.85 million for the second year. The overall goal is to promote effective genomic interventions in primary care settings, contributing to improved health equity and personalized medicine.