The National Institutes of Health (NIH) is inviting applications for the NIDA Animal Genomics Program (U01), aimed at investigating genetic, genomic, and molecular variants associated with substance use disorders (SUD). The program seeks to identify the genetic architecture influencing neural and behavioral traits related to SUD risk, trajectories, and comorbidities, encouraging the use of diverse methodologies, including multi-omics and machine learning approaches. This initiative is critical for advancing the understanding of SUD and developing potential therapeutic targets for addiction treatment. Applications are due by February 11, 2027, with a funding period of up to five years and no budget limit, although costs must be justifiable. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov or visit the program's webpage at https://grants.nih.gov/grants/guide/pa-files/PAR-24-269.html.