The National Institute on Drug Abuse (NIDA) is inviting applications for the Animal Genomics Program (U01) to investigate the genetic, genomic, and molecular variants linked to substance use disorders (SUD). This program aims to identify the genetic architecture influencing neural and behavioral traits associated with SUD risk, trajectories, and comorbidities. Researchers are encouraged to employ a variety of approaches, including multi-omics and machine learning, to explore genetic mechanisms that may reveal therapeutic targets for addiction treatment. A Plan for Enhancing Diverse Perspectives (PEDP) is a mandatory requirement for application, reflecting the NIH's commitment to inclusivity in research. Application deadlines begin on January 11, 2025, with a funding period of up to five years and no limit on the budget, although costs must be justifiable. Eligible applicants encompass a wide range of organizations, including public and private institutions, nonprofits, and foreign entities. The review process will evaluate the scientific merit, innovation, and feasibility of proposals, emphasizing interdisciplinary collaboration. Successful applications will contribute significantly to understanding SUD and enhancing future research efforts in addiction science.