Notice of Intent to Publish a Funding Opportunity Announcement for ML/AI Tools to Advance Genomic Translational Research (MAGen) - Development Sites

Active
Yes
Status
Forecasted
Estimated Post Date
April 26th, 2024
Estimated Close Date
July 26th, 2024
Estimated Award Date
April 15th, 2025
Total Funding
$4,800,000.00
Award Ceiling
$1,600,000.00
Expected No. Awards
3
Opportunity No.
NOT-HG-24-029

Agency

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Summary

The National Institutes of Health (NIH) plans to publish a funding opportunity announcement for ML/AI Tools to Advance Genomic Translational Research (MAGen) - Development Sites. This opportunity aims to explore the feasibility of developing Machine Learning (ML) and Artificial Intelligence (AI) tools that can enhance the accuracy and precision of predicting how individuals with pathogenic genetic variants manifest disease. The objective is to collaboratively identify both genomic and non-genomic factors influencing disease development in individuals carrying pathogenic genetic variants within a research consortium. The ML/AI tools will leverage existing multimodal genomic and non-genomic data and will be cross-validated in genomic translational research settings to ensure their robustness and generalizability. The consortium will also address the ethical, legal, and social implications (ELSI) of integrating ML/AI tools into genomic medicine. The funding opportunity is expected to be published in Spring 2024, with an application due date in Summer 2024.

Description

The National Human Genome Research Institute intends to issue a Notice of Funding Opportunity (NOFO) to solicit applications to explore the feasibility of developing Machine Learning (ML) and Artificial Intelligence (AI) tools that can enhance the accuracy and precision of predicting how individuals with pathogenic genetic variants manifest disease.� The objective of the NOFO is to collaboratively identify both genomic and non-genomic factors influencing disease development in individuals carrying pathogenic genetic variants within a research consortium, ML/AI Tools to Advance Genomic Translational Research (MAGen). This consortium will include the MAGen Sites funded by the NOFO and MAGen Coordinating Center funded by the companion NOFO (see�NOT-HG-24-030). The ML/AI tools will leverage existing multimodal genomic and non-genomic data and will be cross validated in genomic translational research settings to ensure the robustness and generalizability of the tools. In addition, the Consortium will explore the ethical, legal, and social implications (ELSI) of integrating ML/AI tools into genomic medicine through the establishment of an ELSI framework for their development and through implementation of ELSI research projects. The intended NOFO is based on a�concept recently approved by the National Advisory Council on Human Genome Research and accompanying�discussion. This Notice is being provided to allow potential applicants sufficient time to develop collaborations and responsive projects. The NOFO is expected to be published in Spring 2024 with an expected application due date in Summer 2024. This NOFO will utilize the UG3/UH3 activity code. Details of the planned NOFO are provided below.

Opportunity Lifecycle

Title
Type
Grant

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