The National Institutes of Health (NIH) plans to publish a funding opportunity announcement for ML/AI Tools to Advance Genomic Translational Research (MAGen) - Development Sites. This opportunity aims to explore the feasibility of developing Machine Learning (ML) and Artificial Intelligence (AI) tools that can enhance the accuracy and precision of predicting how individuals with pathogenic genetic variants manifest disease. The objective is to collaboratively identify both genomic and non-genomic factors influencing disease development in individuals carrying pathogenic genetic variants within a research consortium. The ML/AI tools will leverage existing multimodal genomic and non-genomic data and will be cross-validated in genomic translational research settings to ensure their robustness and generalizability. The consortium will also address the ethical, legal, and social implications (ELSI) of integrating ML/AI tools into genomic medicine. The funding opportunity is expected to be published in Spring 2024, with an application due date in Summer 2024.