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The Department of Health and Human Services, through the Agency for Healthcare Research and Quality (AHRQ), invites proposals for funding under the Notice of Funding Opportunity (NOFO) PA-23-290, focusing on improving diagnostic safety in ambulatory care settings. The goal is to develop, test, and evaluate strategies and interventions that enhance diagnostic accuracy and quality in varied outpatient settings, addressing significant issues such as diagnostic errors that impact millions annually. Applications are encouraged to consider factors like health equity and the involvement of diverse populations in their research designs. Funding up to $500,000 per year for a maximum of four years is available, with a total budget cap of $2 million for the entire project. The applications are due by January 25, 2024, and will undergo a scientific merit review approximately four months post-submission. The AHRQ aims to fund projects that not only focus on diagnostic accuracy but also promote a more equitable healthcare landscape. Researchers from eligible institutions, including higher education and nonprofit organizations, are encouraged to collaborate and propose innovative solutions addressing both diagnostic safety and disparities in healthcare. This initiative represents a continued effort by the AHRQ to mitigate risks and improve patient outcomes across diverse medical practices.