The National Institutes of Health (NIH) is announcing a forthcoming funding opportunity titled "BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain" under the U01 cooperative agreement mechanism. This initiative aims to solicit applications for research that investigates fundamental questions in human neuroscience through direct access to the brain, leveraging surgical procedures to explore how the brain senses, perceives, and engages in various cognitive functions. The opportunity encourages collaborative efforts among diverse teams, including clinicians, scientists, and engineers, to propose innovative research plans that could lead to significant insights into nervous system disorders. Interested applicants should prepare for the application process, as the estimated synopsis will be posted on November 28, 2025, with a closing date for applications expected by February 27, 2026. For further inquiries, potential applicants can contact Dr. Hermon R. Gebrehiwet at 240-328-8371 or via email at BRAINResOppHu@ninds.nih.gov.