The U.S. National Science Foundation (NSF) is offering a federal grant opportunity titled "Smart Health and Biomedical Research in the Era of Artificial Intelligence and Advanced Data Science." This initiative aims to support transformative, high-risk, high-reward advancements in computer and information science, engineering, and related fields to address critical challenges in biomedical and public health. The program encourages the formation of interdisciplinary teams to develop innovative methods for data collection, analysis, and interpretation, ultimately enhancing health outcomes. The estimated total program funding is $20 million, with an award ceiling of $1.2 million and an expected 16 awards to be made. Proposals are due by October 3, 2025, and interested applicants can reach out to NSF grants.gov support at grantsgovsupport@nsf.gov for assistance.