The Department of Health and Human Services is inviting applications for a Coordinating Center within a pilot program for Population Genomic Screening in Primary Care, spearheaded by the National Institutes of Health (NIH). The initiative, under funding opportunity number RFA-HG-24-022, aims to implement evidence-based screening for common genomic conditions, primarily in diverse primary care settings. The network will consist of multiple Clinical Groups and a Sequencing Center, focusing on enhancing community engagement, following protocols for genomic screening, and increasing awareness of genetic conditions among underserved populations. The objectives include screening for 4-7 genomic conditions, achieving a target enrollment of 20,000 patients, and ensuring a minimum 55% enrollment from health disparity populations. The timeline encompasses protocol development, patient recruitment, data collection, and analysis over a 5-year period. The goal is to effectively integrate genomic screening into primary care and evaluate its impact on patient outcomes through collaboration with various stakeholders. This funding opportunity emphasizes the importance of health equity, including addressing ethical considerations around genomic testing and ensuring robust educational resources for primary care providers.