The National Institutes of Health (NIH) is offering a grant opportunity titled "Adolescent Overdose Prevention and SUD Treatment Initiative (R21 - Clinical Trial Not Allowed)" aimed at addressing the critical issue of adolescent illicit fentanyl use and overdose patterns among youth aged 12-18. This initiative encourages exploratory and developmental research to identify effective overdose prevention strategies and substance use disorder treatment methods, particularly focusing on high-risk adolescents and the alarming trends in overdose deaths, which saw a 94% increase from 2019 to 2020. The NIH anticipates committing approximately $1,000,000 to support 1-2 awards, with individual budgets capped at $275,000 over a two-year period. Applications are due by March 13, 2024, and interested parties can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.