DOD Amyotrophic Lateral Sclerosis, Therapeutic Development Award
ID: 358724Type: Posted
Overview

Buyer

Dept. of the Army -- USAMRAA (DOD-AMRAA)

Eligible Applicants

Unrestricted

Funding Category

Science and Technology and other Research and Development

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/358724
Timeline
    Description

    The Department of the Army, through the US Army Medical Research and Development Command (USAMRAA), is offering the Amyotrophic Lateral Sclerosis Research Program (ALSRP) Therapeutic Development Award (TDA) to support innovative research aimed at developing therapies for Amyotrophic Lateral Sclerosis (ALS). This grant program seeks applications that demonstrate proof-of-concept efficacy in preclinical models of ALS, with a focus on empirical therapeutic studies and the development of mechanism-specific biomarkers to enhance trial design and patient selection. With an estimated total funding of approximately $9.8 million, the program anticipates awarding about four grants, each capped at $1.5 million for a maximum duration of three years. Interested applicants must submit a pre-application by June 6, 2025, followed by a full application due by August 27, 2025. For further inquiries, applicants can contact the CDMRP Help Desk at help@eBRAP.org or call 301-682-5507.

    Point(s) of Contact
    help@eBRAP.org
    Files
    Title
    Posted
    A03.pdf
    The Department of Defense's FY25 Amyotrophic Lateral Sclerosis Research Program (ALSRP) has announced the Therapeutic Development Award (TDA) to support innovative ALS research from preclinical validation to FDA Investigational New Drug studies. The program will allocate approximately $9.8 million for about four awards, each capped at $1.5 million and intended for a maximum three-year period. Application deadlines include a pre-application due by June 6, 2025, and a full application by August 27, 2025. Eligible applicants span both extramural and intramural organizations and should demonstrate proof-of-concept efficacy in preclinical models of ALS. Key goals include empirical therapeutic studies with a focus on biomarker development alongside therapeutic efforts. Non-clinical studies are encouraged, leveraging existing human specimen resources rather than recruiting new participants. Applications must highlight proposed strategies for collaboration, transition to clinical testing, and regulatory considerations, alongside comprehensive scientific and budget plans. The review process includes a dual-tier evaluation of technical merit and programmatic relevance, with final funding decisions reflecting the alignment with ALSRP objectives and available funding. This initiative illustrates a concerted effort to advance ALS treatment options significantly while aiming to benefit military Service Members, Veterans, and the general public.
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