The United States Agency for International Development (USAID) is forecasting a new health initiative titled "Systems to End the Malaria Burden through Meaningful Engagement-I (SEMBE I)" aimed at engaging local organizations in Cameroon to combat malaria. This opportunity is structured as a Request for Information (RFI) to gather feedback from interested local entities regarding the design of a five-year health activity, with a focus on meaningful engagement in malaria prevention and treatment efforts. The initiative underscores the importance of local partnerships in addressing health challenges, particularly in the context of malaria, which remains a significant public health issue in the region. Interested organizations are encouraged to participate in a pre-solicitation conference scheduled for September 15, 2022, in Yaoundé, Cameroon, and must submit their responses to the RFI by September 22, 2022. For further inquiries, contact Mohammad Baddar at mbaddar@usaid.gov or via phone at +233302741200.