The National Institutes of Health (NIH) is offering a federal grant opportunity titled "Extracellular Vesicle Therapeutics for Regenerative Medicine (ExTReMe)" aimed at advancing research on extracellular vesicles (EVs) as therapeutics in regenerative medicine. This cooperative agreement seeks to support the translation of EV-based therapeutics, focusing on their role in intercellular communication and potential applications in tissue repair and regeneration. Eligible applicants for this discretionary funding opportunity include small businesses, with no cost-sharing or matching requirements. Interested parties should note that the estimated synopsis post date is October 15, 2025, with a closing date of February 17, 2026, and an anticipated award date of December 17, 2026. For further inquiries, applicants can contact Christine Happel, Ph.D., at christine.happel@nih.gov or by phone at 240-472-7550.