Catalyze: Product Definition for Small Molecules, Biologics and Combination Products - Target Identification and Validation, and Preliminary Product/Lead Series Identification (R61/R33 Clinical Trials Not Allowed)
ID: 357334Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/357334

Additional Information

http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-26-017.html
Timeline
    Description

    The National Institutes of Health (NIH) is offering a funding opportunity titled "Catalyze: Product Definition for Small Molecules, Biologics, and Combination Products," aimed at supporting early-stage translational research for heart, lung, blood, and sleep disorders. This initiative employs a phased approach (R61/R33), where the R61 phase focuses on identifying and validating therapeutic candidates, while the R33 phase involves lead series identification for preclinical testing, emphasizing innovation and addressing therapeutic gaps. The total funding commitment is approximately $4.47 million per fiscal year from 2026 to 2028, with a maximum budget of $400,000 per year for each phase, and applications are due by December 23, 2027. Interested applicants can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    RFA-HL-26-017-Full-Announcement.html
    RFA-HL-26-017.html
    The Department of Health and Human Services, through the National Institutes of Health (NIH), announces a funding opportunity titled "Catalyze: Product Definition for Small Molecules, Biologics, and Combination Products." This initiative aims to support early-stage translational research for the treatment of heart, lung, blood, and sleep disorders. The funding is structured in a phased approach (R61/R33), where the R61 phase focuses on identifying and validating therapeutic candidates, while the R33 phase involves lead series identification for preclinical testing. Proposals should emphasize innovation and address current gaps in therapeutic options. Each application is expected to outline clear milestones for both phases, with a three-year maximum project period and an emphasis on collaboration with Accelerator Partners to enhance commercialization prospects. A cost-matching component is required for the R33 phase. The total funding commitment is approximately $4.47 million for each fiscal year from 2026 to 2028, with a maximum budget of $400,000 per year for each phase. Applications are encouraged from various eligible organizations, including higher education institutions and nonprofits, and must comply with NIH guidelines. This funding opportunity seeks to improve research capacity and enhance the development of effective therapeutics in alignment with the NHLBI mission.
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