The National Institutes of Health (NIH) is offering a funding opportunity through the INCLUDE Project, specifically for Clinical Trials Phased Awards aimed at advancing research on Down syndrome. This grant program encourages Exploratory/Developmental Phased Innovation (R61/R33) applications to develop clinical trials addressing critical health conditions associated with Down syndrome, with a focus on milestone-driven research. The total funding available for this initiative is approximately $3 million, with an expected four awards, and applications may request a minimum of $100,000. Interested applicants should note that the project period can extend up to five years, with the R61 phase supporting preliminary studies for up to two years, followed by a potential R33 phase for clinical trial support. For further inquiries, applicants can contact Laurie Ryan, PhD, at 301-496-9350 or via email at ryanl@nih.gov. The application deadline is set for February 19, 2026, with awards anticipated to be announced by September 1, 2026.