The Centers for Disease Control and Prevention (CDC) has issued a Notice of Funding Opportunity (NOFO) titled "Health Promotion and Disease Prevention Research Centers: 2025 Special Interest Project Competitive Supplements" (RFA-DP-25-126) to provide supplemental funding for the Health Promotion and Disease Prevention Research Centers (PRCs). The funding aims to support high-quality applied research to inform public health practices and reduce major causes of illness, disability, and death in the U.S. The total funding available is estimated at $21,858,000, with up to 12 awards anticipated. Eligible applicants must be previously funded PRCs under RFA-DP-24-004. Research proposals should focus on health topics aligned with the Healthy People 2030 objectives, such as cancer, diabetes, and obesity. Applications are required to be submitted electronically through Grants.gov by February 28, 2025, with a Letter of Intent due by February 5, 2025. The funding mechanism is a cooperative agreement, signifying substantial federal involvement in the projects. The document details eligibility criteria, application requirements, evaluation criteria, and administrative information associated with the funding opportunity. This initiative reflects a commitment to addressing public health challenges through collaborative, evidence-based research strategies.