The National Institutes of Health (NIH) is inviting applications for Cancer Center Support Grants (CCSGs) aimed at supporting NCI-designated Cancer Centers, including Comprehensive, Clinical, and Basic Cancer Centers. Applicants must demonstrate a substantial base of NIH cancer-focused funding, with requirements of $10 million for Clinical and Comprehensive Centers, and $6 million for Basic Centers for new applicants, while renewal applicants must also meet a $10 million threshold. These grants are crucial for advancing interdisciplinary research to reduce cancer incidence, mortality, and morbidity, providing resources for scientific leadership, shared facilities, and administrative costs over a five-year term, with a possible two-year extension based on merit. Interested institutions can contact the Office of Cancer Centers at ncicenters-r@mail.nih.gov for further information, with applications due by September 25, 2028.