The National Institutes of Health (NIH) is offering the INCLUDE Project: Transformative Research Awards for Down syndrome, aimed at advancing innovative research to improve health and quality of life for individuals with Down syndrome. This funding opportunity invites applications for groundbreaking research that can establish new scientific paradigms or develop transformative technologies related to Down syndrome and its co-occurring conditions, with no preliminary data required. The program has an estimated total funding of $3 million, with individual awards ranging from $250,000 to $500,000, and is expected to support approximately four projects. Interested applicants can reach out to Dr. Charlene Schramm at schrammc@nih.gov or by phone at 301-402-3793, with applications due by February 19, 2026, and anticipated awards announced by September 1, 2026.