The Department of Health and Human Services, specifically the Office of Assistant Secretary for Preparedness and Response (BARDA), is seeking proposals for the development of NextGen Oral Formulation Vaccines for COVID-19 through a Request for Project Proposals (RPP) issued via the Rapid Response Partnership Vehicle (RRPV) Consortium. The primary objective of this solicitation is to advance oral vaccine platforms and technologies into a proof-of-concept Phase 1 clinical trial, enhancing the understanding of their potential and improving COVID-19 solutions to bolster preparedness against future health security threats. This initiative is critical in the ongoing efforts to combat COVID-19 and prepare for similar health crises. Interested parties can access the full RPP and additional consortium information at www.rrpv.org, and inquiries can be directed to Rebecca Harmon at rebecca.harmon@ati.org.