The Department of Health and Human Services, specifically the National Institutes of Health (NIH), intends to procure a 10X Genomics, Inc Chromium instrument on a sole source basis for its Clinical Center's Department of Laboratory Medicine. This procurement includes a Chromium X and accessory kit, dual index kits, GEM-X Flex gene expression chip kits, and other related items essential for conducting single-cell gene expression experiments using patient-derived samples. The 10X Genomics Chromium instrument is critical for analyzing mRNA levels at the single-cell level, and its use is validated for quality-controlled processes within the NIH. Interested parties capable of providing similar products must submit a capability statement by March 22, 2025, to Emeka Onyejekwe at emeka.onyejekwe@nih.gov for consideration.