The Defense Threat Reduction Agency (DTRA) has released Broad Agency Announcement HDTRA1-25-S-0001, soliciting research proposals aimed at fundamental research to counter Weapons of Mass Destruction (C-WMD) from accredited institutions, including universities, industry, and not-for-profit organizations. The announcement is effective from October 1, 2024, to September 30, 2034, and emphasizes grants as the primary funding mechanism. Applicants are encouraged to submit proposals that demonstrate significant university participation and address long-term challenges in C-WMD. The evaluation of submissions will occur in two phases, starting with "pre-application white papers," followed by invited proposals based on their merit. Proposals can span up to five years, with annual funding ranging from $25K to $1M, depending on project scope. DTRA prioritizes innovative approaches and direct contributions to C-WMD science, emphasizing participation from students and interdisciplinary collaboration. Notably, all applications must comply with DTRA's guidelines and be submitted via www.grants.gov. This announcement aims to advance fundamental scientific knowledge while enhancing educational efforts related to C-WMD defense, reflecting the government's commitment to safety and security in national defense.