The U.S. Customs and Border Protection (CBP) seeks a modernized Forensic Laboratory Information Management System (LIMS) to enhance efficiency and reliability in managing forensic and scientific operations. The outdated existing system necessitates critical replacement due to its high customization and error-prone nature. The proposed COTS LIMS must encompass a wide range of functionalities, including secure evidence management, chain of custody tracking, customizable workflows, robust reporting capabilities, and comprehensive electronic signature support. Key requirements include maintaining data integrity through secure audit trails, supporting evidence lifecycle management, and ensuring compliance with federal, state, and local regulations. The system must allow for customized configurations tailored to various functional areas such as digital forensics and narcotics. Furthermore, vendor responses will be evaluated based on how well their offerings meet specific, identified needs across multiple modules, from case management to resource tracking. Given the stringent operational standards, the selected vendor must provide a fully integrated solution that assures future scalability and accreditation compliance, highlighting the ongoing commitment of CBP to uphold forensic integrity in its invaluable work to protect the homeland.