Presolicitation HEALTH AND HUMAN SERVICES, DEPARTMENT OF NATIONAL INSTITUTES OF HEALTH is seeking proposals from small businesses to develop innovative technologies for the treatment and prevention of Pediatric Cancers and/or Rare Cancers. The proposals should focus on the development of therapeutic or preventative technologies, devices, diagnostic technologies, or digital health tools. The aim is to demonstrate technical feasibility and proof-of-concept for highly innovative and potentially transformative technologies. The solicitation encourages proposals for rare cancers with a 5-year survival rate of less than 50%. The proposals should include experiments to obtain initial de-risking and proof-of-concept data. The awards will also include requirements to enhance entrepreneurship skills and develop a business model and commercialization plan. This is a total small business set-aside solicitation, and only eligible small businesses with no more than 500 employees will be considered. The solicitation is anticipated to be available on or around April 12, 2024, with a closing date in late September for receipt of proposals. Other SBIR and STTR contract and grant opportunities are also available. For more information, please refer to the NCI SBIR Program website.