The DARPA-SN-26-27 Special Notice outlines the mandatory abstract submission process for the Generative Optogenetics (GO) program. Proposers must use Attachment A, adhere to specific formatting (5-page limit, 8-1/2 by 11-inch paper, 1-inch margins, 12-point font), and ensure unclassified content. Abstracts require a cover sheet, executive summary, background and expertise, scope of work, and basis of estimate. A bibliography is optional but limited. DARPA will review abstracts and either invite or decline full proposal submissions, with an invitation being a prerequisite for full proposal review. The document details requirements for team expertise, recruitment plans, project leadership, and a notional budget, excluding honorariums. The goal is to align proposals with the GO program's need for responsible development, regulation, and commercialization of GO technologies, addressing biosecurity, regulatory policy, and commercialization challenges.

DARPA's Generative Optogenetics (GO) program seeks facilitators for three working groups: Biosecurity (BSWG), Regulatory Policy (RPWG), and Commercialization (ICCG). These groups will address challenges in biosecurity, regulation, and market entry for GO technologies, which enable direct programming of living cells via optical stimuli. The BSWG will analyze misuse risks and develop policy recommendations. The RPWG will identify regulatory concerns and propose guidelines. The ICCG will provide commercialization support to performers, including pitch development and investor connections. Organizations must submit abstracts by January 26, 2026, and full proposals by March 2, 2026, focusing on one working group. Budgets are capped at $1.25M for BSWG/RPWG and $1.5M for ICCG over 42 months. Evaluation criteria prioritize scientific/technical merit, proposer capabilities, relevance to DARPA's mission, and cost/schedule realism. Collaboration among the working groups and with technical performers is essential for responsible development and deployment of GO technologies.