The Department of Commerce, specifically the National Institute of Standards and Technology (NIST), is planning to negotiate a sole-source procurement for a Holographic Particle Analyzer from Spheryx, Inc., based in New York, NY. This specialized instrument is crucial for NIST’s Bioprocess Measurement Group, which is dedicated to characterizing particle sizes and concentrations in biotherapeutics, providing comprehensive measurements of particle size and index of refraction. The xSight Particle Analyzer, capable of measuring particles in a dynamic size range of 500 nm to 10 µm, significantly enhances particle measurement capabilities in biomanufacturing and particle metrology. Interested parties that can meet the requirements may submit responses until March 7, 2025, and should contact Tish Walker at latish.walker@nist.gov for further information.