The Library of Congress (LOC) is issuing a Request for Information (RFI) to explore the feasibility of utilizing synthetic DNA for the long-term preservation of its extensive digital collections, which currently exceed 31 petabytes. The objectives include encoding 1.0TB of various data formats—such as video, audio, text, and images—onto synthetic DNA, ensuring high accuracy in the writing process, validating preservation techniques, and documenting the overall process and findings. This initiative is significant as it aims to enhance data preservation methods while supporting the Library's future needs, particularly in light of the upcoming 250th anniversary of the Declaration of Independence. Interested vendors should direct inquiries to Riley Leonhardt at rleonhardt@loc.gov or Betsy Lewis-Matsuoka at bmatsuoka@loc.gov, with the project expected to be completed within one year under a fixed-price contract structure.