The National Institutes of Health (NIH), specifically the National Institute of Allergy and Infectious Diseases (NIAID), is seeking proposals for the establishment of a Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB). This initiative aims to coordinate and conduct the design, synthesis, and testing of chemical libraries of novel small molecules and natural products targeting Gram-negative bacterial pathogens, addressing the critical issue of multidrug-resistant bacteria. The contract will encompass four key areas: Library Design, Compound Synthesis, Compound Testing, and Compound Management, with an estimated 28,000 direct labor hours required for the base year and each option period. Proposals must be submitted electronically via the NIAID electronic Contract Proposal Submission (eCPS) website, with the RFP expected to be available on or about November 30, 2024. Interested parties can contact Aytaj Vily at aytaj.vily@nih.gov or 301-761-5131 for further information.