Harnessing Artificial Intelligence and Polypharmacology to Discover Pharmacotherapeutics for Substance Use Disorders (R41/R42 Clinical Trials Not Allowed)
ID: RFA-DA-25-053Type: BOTH
Overview

Topic

Harnessing Artificial Intelligence and Polypharmacology to Discover Pharmacotherapeutics for Substance Use Disorders (R41/R42 Clinical Trials Not Allowed)

Agency

Department of Health and Human ServicesNational Institutes of Health

Program

Type: STTRPhase: BOTHYear: 2024

Topic Link

https://www.sbir.gov/node/2504579

Additional Information

https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-053.html
Timeline
    Description

    The Department of Health and Human Services, specifically the National Institutes of Health, is seeking proposals for the topic of "Harnessing Artificial Intelligence and Polypharmacology to Discover Pharmacotherapeutics for Substance Use Disorders (R41/R42 Clinical Trials Not Allowed)". This solicitation aims to leverage AI/ML tools to identify pharmacotherapeutic development candidates with lower toxicity and higher efficacy for the prevention or treatment of substance use disorders (SUDs). The traditional drug discovery paradigm of single-target-based approaches has limitations in addressing the complex mechanisms and polysubstance use associated with SUDs. Polypharmacology, the study of how drug molecules interact with multiple targets, is emerging as a new paradigm for drug development in multifactorial diseases like SUDs. The use of AI/ML technologies trained in polypharmacology can enhance the discovery and development efforts for SUD pharmacotherapeutics by identifying the best targets, designing effective multi-target directed ligands (MTDLs), and predicting the effects of binding to multiple biological targets. The research objectives include identifying and validating disease targets, screening potential compounds, developing assays, synthesizing novel compounds, and conducting in vitro and in vivo studies. The Small Business Technology Transfer (STTR) program is a phased program, with Phase I focused on establishing technical merit and feasibility, and Phase II aimed at advancing the technology towards commercialization. The Fast Track option allows for the submission and review of Phase I and Phase II grant applications together, expediting the award decisions and funding for projects with high potential for commercialization.

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